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An introduction to systems biology: Design principles of biological circuits

(2019) - Uri Alon

Abstract

Notes

Part one: Network motifs – Transcription networks basic concepts – Autoregulation – The feed forward loop – Temporal programs and the global structure of transcription networks – Positive feedback, bistability and memory – How to build a biological oscillator – Robustness – Kinetic proofreading and conformational proofreading – Part two: Robust signalling – Chemotaxis – Fold-change detection – Dynamical compensation and mutal resistance in tissues – Robust spatial patterning in development – Part three: Optimality – Optimal gene circuit design – Multi-objective optimality in biology – Modularity